Search results for "Novel technique"
showing 10 items of 15 documents
Sequenom MassARRAY Technology for the Analysis of DNA Methylation
2016
Abstract DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression and is involved in the development of different pathologies such as obesity, Alzheimer's, and cancer. In this chapter, we have analyzed in depth the Sequenom MassARRAY® technology for the analysis of DNA methylation with special emphasis on its applications in clinical practice. In recent years, the Sequenom EpiTYPER® system technology has emerged as a novel technique for methylation analysis that offers a high range of options with great performance and several advantages.
Wideband modeling of cascaded H-plane waveguide junctions using the generalised impedance matrix representation
2009
A strong interest in H-plane waveguide components composed of a large number of cascaded planar junctions is recently renewed. Therefore, the more efficient development of full-wave analysis tools of such devices is again receiving consideration, specially for its potential use within modern design tools. A novel technique for providing the wideband generalised impedance matrix representation of the inductive devices in the form of pole expansions, thus extracting the most expensive computations from the frequency loop is proposed. For such purpose, the whole device is first decomposed into simpler building blocks, i.e. planar junctions and uniform waveguides, which are modelled in terms of…
Hot Topic Water-filtered infrared-A radiation: a novel technique for localized hyperthermia in combination with bacteriochlorophyll-based photodynami…
1999
A novel application of an infrared-A (IR-A) radiation source equipped with a water-filter in the radiation path is described, which allows for tumour treatment with a simultaneous combination of localized hyperthermia (HT) and bacteriochlorophyll-serine (Bchl-ser) based photodynamic therapy (PDT). Using this system, the IR-A radiation was used to heat tumours to 43 degrees C for 60 min, while at the same time activating the Bchl-ser which was injected i.v. at a dose of 20 mg/kg, 10 min following commencement of HT. The growth of tumours undergoing this combined therapy was compared to that of tumours undergoing HT alone or sham-treated controls. Within the 90 day observation period, 100% of…
An evaluation of the antireflux properties of sodium alginate by means of combined multichannel intraluminal impedance and pH-metry.
2005
Summary Background : Alginate-based preparations act as mechanical antireflux barrier, which can reduce both acid and non-acid reflux events and limit the proximal migration of oesophageal refluxate. Aim : To evaluate all the above features with a novel technique, multichannel electrical impedance and pH-metry. Methods : Ten reflux patients underwent stationary impedancemetry and pH-metry after eating a refluxogenic meal. They were studied 1 h in basal conditions and 1 h after taking 10 mL of Gaviscon Advance. In both sessions, measurements were obtained in right lateral and supine decubitus. Results : Alginate preparation was able to decrease significantly (P < 0.05) the number of acid ref…
Dual-Polarization Interferometry: A Novel Technique To Light up the Nanomolecular World
2015
[EN] The challenging lecture given in 1959 by physicist and Nobel Prize awarded R. P. Feynman: “There's plenty of room at the bottom” is considered to be the starting point for nanotechnology. With this peculiar title, Feynman encouraged researchers to explore beyond the atomic level and predicted exciting new phenomena that might revolutionize science and technology. Among these pioneering researchers are Eric Betzig, Stefan W. Hell and William E. Moerner, who have been awarded with the Nobel Prize in Chemistry 2014 for developing the super-resolved fluorescence microscopy. However, it is important to remark that the exploration of this amazing nanomolecular world began in the early 1980s …
A Novel Technique for Modeling Vehicle Crash using Lumped Parameter Models
2021
This paper presents a novel technique for modeling a full frontal vehicle crash. The crash event is divided into two phases; the first until maximum crush and the second part when the vehicle starts pitching forward. This novel technique will help develop a three degrees of freedom (DOF) lumped parameter model (LPM) for crash and support in the vehicle development process. The paper also highlights the design process for reducing vehicle pitching in occupant protection load cases. The model has been validated against a finite element (FE) simulation of a full frontal crash of a Chevrolet Silverado developed by the National Highway Traffic Safety Administration (NHTSA), and the LPM shows goo…
A Novel Technique for Monitoring the W-Beam Guardrails
2014
The paper addresses the problem of the measurement of guardrails’ deformations by means automatic analysis of optical images. The technique is founded on the analysis of high-resolution photos, obtained by means of 3D camera installed into a data vehicle. The novel methodology has been used to calculate the longitudinal safety barrier deformations for one W-beam guardrails installed along a rural road in Italy. The procedure has shown that digital image analysis can be used with the aim to monitoring guardrails and, therefore, for guarantee reasonable levels of protection against serious ran-off-road crashes.
Time response of the vision binocularity by use of dynamic suppression of retinal images
1999
We present a novel technique for determination the stereopsis dynamic response, using as stimulus a random dot stereopair. Stereopsis can be evoked or depressed by continuous or flash illumination of the stimulus with simultaneous control of a special light scattering obstacle build in the visual path of one eye. The obstacle--a thin plate of electrooptical PLZT ceramics-- exposes (by applying of the voltage to semitransparent gold electrodes deposited on both surfaces of the plate) light scattering so blurring the retinal image, similar as for an eye with a cataract, depressing stereopsis. The random dot stereopair contains contours of images with a different stereodisparity. The PLZT plat…
A Novel Technique Using Polytetrafluoroethylene Tape to Solve Screw Loosening Complication in Implant-Supported Single Crowns
2020
This study aimed to analyze a novel technique to make screws with greater untightening resistance and to solve screw loosening in implant-supported single crowns. Thirty grade IV titanium straight abutments were screwed onto 30 external hex implants using grade IV titanium screws (30 Ncm). They were exposed to cyclic loading (300,000 cycles, 200 N). Samples were divided into 4 groups (15 samples per group): new screws (SCREW group) (control), reused screws (rSCREW group), new screws wrapped with polytetrafluoroethylene (PTFE) tape (PTFE group), and reused screws wrapped with PTFE tape (rPTFE group). Reverse torque values (RTVs) were recorded with a digitally calibrated implant motor. Mean R…
Measurements of the stopping forces for heavy ions in Ge, Ag and Au using novel ‘polka-dot’ detectors
2006
Measurements of the stopping forces for C-14, N-14 and O-16 ions in Ge and Au, for N-14 and F-19 ions in Ag, as well as for F-19 ions in Au have been made, respectively. A novel technique, reported recently, using PIN diodes coated directly with the stopping medium in a polka dot pattern was used. This provided a set of precise, self-consistent measurements on the same stopping medium. Results show small but significant deviations from SRIM stopping predictions and are also compared to a recently-developed empirical stopping force predictor.